QuikRead go CRP

Accurate measurement of C-reactive protein (CRP) can be critical in the clinical management of a patient with symptoms of infection. The fast and easy-to-use QuikRead go CRP test can be performed near the patient and the CRP result is immediately available to support the diagnosis. The QuikRead go CRP test helps to identify patients who benefit from antibiotics and it is valuable in monitoring the treatment outcome.

The ready-to-use system, consisting of an instrument and reagent kits, provides fast and accurate results. The healthcare professional can choose from a variety of QuikRead go tests to get the most out of the QuikRead go system.

QuikRead go CRP provides you with

Reliable results

• High quality: comparable to laboratory test results
• Reproducible CRP results within a range of 5 - 200 mg/l

Quick results

• Results within 2 minutes

Easy to use

• No manual steps
• Automatic hematocrit correction
• Performed on a finger-prick blood sample. Venous blood, plasma or serum can also be used.

This version of QuikRead go CRP is not registered in the USA (link to the US product version: QuikRead go CRP for the USA).

Test results should never be used alone, without a complete clinical evaluation.

CRP (C-reactive protein) is an acute phase protein synthesized in the liver. Production of CRP is rapidly induced in response to infection, inflammation and tissue injury. Measurement of CRP may be helpful in the clinical management of a patient with symptoms of an infection. When evaluated in the light of the patient’s clinical condition, measurement of CRP can assist healthcare professionals in differentiating between bacterial and viral infections and in rationalising antibiotic therapy. Monitoring CRP levels also provides an objective means for assessing treatment response, as CRP levels fall rapidly as a result of an effective therapy.

Specific features of CRP

• normally present in very low concentrations in the blood of healthy people; 99% have levels of <10 mg/l¹
• uncomplicated viral infections mostly induce (with some exceptions) a very modest elevation or none at all¹
• in bacterial infections, concentrations increase markedly¹
• elevated concentrations can be detected within 6 - 12 h after onset of an inflammatory stimulus, reaching maximum within 24 - 48 h^2,3
• rise in concentrations corresponds to severity of infection¹
• concentrations fall rapidly when the patient responds to antibiotic treatment¹
• normalisation of the concentration may indicate that the duration of the treatment has been sufficient and the treatment can be discontinued^1,4,5

1. Pepys MB. The acute phase response and C-reactive protein. In: Warrell DA, Cox TM, Firth JD, Benz EJ, eds. Oxford Textbook of Medicine, 4th ed. Oxford University Press, 2003. Vol 2, p.150 – 156.
2. Bjerrum L. C-reactive protein measurement in general practice may lead to lower antibiotic prescribing for sinusitis. Br J Gen Pract 2004; 54: 659 - 662.
3. Pepys MB. C-reactive protein fifty years on. Lancet 1981; 1: 653 -657.
4. Philip AGS, Mills PC. Use of C-reactive Protein in Minimizing Antibiotic Exposure: Experience With Infants Initially Admitted to a Well-Baby Nursery. Pediarics 2000; 106.
5. Ehl S et al. C-Reactive Protein Is a Useful Marker for Guiding Duration of Antibiotic Therapy in Suspected Neonatal Bacterial Infection. Pediatrics 1997; 99: 216 - 221.

Regular use of QuikRead go CRP Controls is recommended.

Recommended Controls:

• 153764 QuikRead go CRP Control (~25 mg/l with blue colour)
• 153763 QuikRead go CRP Control High (~75 mg/l with blue colour)

Optional Controls:

• 68296 QuikRead CRP Control (~25 mg/l)

Antibiotics are a cornerstone of the management of bacterial infections. 80 - 90% of antibiotics are prescribed in primary care, and up to 80% of these are used to treat acute respiratory tract infections¹. It is estimated that approximately 50% of all antibiotic prescriptions are unnecessary². Although most of both upper and lower respiratory tract infections are self-limiting and caused by viruses, antibiotics are frequently used to treat these conditions. Unnecessary and inappropriate use of antibiotics favours the emergence and spread of resistant bacteria. Antibiotic resistance is a major public health concern, which could cause harm to a large number of patients worldwide if infections are no longer susceptible to common medicines used to treat them. Therefore, antibiotics should be used with caution and only when necessary³.

The use of antibiotics in primary care varies considerably between countries, which is unlikely to be caused by differences in the frequency of bacterial infections. There is a clear correlation between the use of antibiotics and the emergence of antibiotic resistance^4-6. As stated by the World Health Organization (WHO)³, restricting an inappropriate and excessive antibiotic use is important to slow down or even reverse the development of antibiotic resistance.

The QuikRead go CRP test helps healthcare professionals to identify those patients who need - and particularly those who do not need - antibiotic therapy. It is also important to know whether the antibiotics will affect the course of the illness^7,8. QuikRead go CRP is useful for following up the effect of treatment. With accurate information, patients can be more easily reassured that symptomatic treatment will be sufficient. On the other hand, a high QuikRead go CRP reading would suggest a bacterial infection requiring antibiotic treatment.

1. Goossens HF, M.; Vander, S.R.; Elseviers, M. Outpatient antibiotics use in Europe and association with resistance: a cross-national database study. Lancet 2005; 365:579-587.
2. Centers for Disease Control and Prevention (CDC). Antibiotic Resistance Threats in the United States 2013.
3. World Health Organization. Antimicrobial resistance: global report on surveillance 2014.
4. Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect 2009; 15 Suppl 3:12-15.
5. European Centre for Disease Prevention and Control. Antimicrobial consumption. Annual epidemiological report for 2016. Stockholm, 2018.
6. Bronzwaer SLAM, Cars O, Buchholz U et al. A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerging infectious diseases 2002; 8:278-282.
7. Bruns AH, Oosterheert JJ, Hak E, Hoepelman AI. Usefulness of consecutive C-reactive protein measurements in follow-up of severe community-acquired pneumonia. Eur Respir J 2008; 32:726-732.
8. Coelho L, Povoa P, Almeida E et al. Usefulness of C-reactive protein in monitoring the severe community-acquired pneumonia clinical course. Crit Care 2007; 11:R92.

Marketing and sales materials

QuikRead go CRP and CRP+Hb Brief Instructions (EN)

QuikRead go Family Brochure (EN)

QuikRead go Technical Specifications (EN)

Instructions for Fingertip Blood Collection (EN)

QuikRead go Control Information (EN)

Stories

Targeted antibiotic use in primary healthcare (EN)

Tackling drug-resistant infections globally - the final report published (EN)

Videos

Instructions for use

(For informative use only. Kindly always refer to the latest package insert in the kit.)

QuikRead go CRP IFU (FI, SE, NO, DK), 133891, 135172, 135174

QuikRead go CRP IFU (GB, DE, FR, IT), 135171, 135283

QuikRead go CRP IFU (ES, PT, NL, GB), 135171, 135283

QuikRead go CRP IFU (SI, RS, HR, GR), 135171, 135283

QuikRead go CRP IFU (CZ, SK, HU, PL), 135171, 135283

QuikRead go CRP Controls IFU (GB, DE, FR, ES, IT, CZ, HU, PL, SK, NL, EE, LT, SE, NO, DK, FI), 153765, 153764, 153763

QuikRead CRP Control IFU (GB, DE, CN, ES, IT, CZ, FR, SK, SI, SE, NO, DK, FI), 68296

Safety Data Sheet

QuikRead go CRP SDS (EN) 135171, 135283, 133891, 135172, 135174

QuikRead go CRP Control SDS (EN) 153764

QuikRead go CRP Control High SDS (EN) 153763

QuikRead CRP Control SDS (EN) 68296

Is it possible to use QuikRead CRP kits for QuikRead go?

No, for QuikRead go you can only use QuikRead go CRP kits. QuikRead go requires a bar code on the cuvette, whereas QuikRead 101 uses a magnetic card.

The QuikRead go instrument gives me a result of > 200 mg/l, but I would like to get an exact CRP result. Is it possible?

When using plasma/serum samples you can dilute the sample with 0.9 % NaCl before adding it to the cuvette. The recommended dilution is 1+3. Remember to multiply the result by 4.

I accidentally left a QuikRead go CRP kit at room temperature for a weekend. Can I still use it?

Yes, you can use the kit. The kit can be stored at room temperature (18 - 25 °C) for one month. If it is used at room temperature during daily working hours (7.5 hours) and stored at 2 - 8 °C after finishing work, the kit will remain stable for 3 months.

Can I use controls other than QuikRead CRP Controls with the QuikRead go CRP kit?

Yes, you can use other commercially available controls. The acceptable control limits must be defined with the precision results gained with the QuikRead go instrument. The blanking process might not succeed if you use a control which contains artificial red blood cells because they might not haemolyse normally.

Why do QuikRead go CRP kit components have different expiration dates and why does the kit have shorter shelf life than some of the components?

The kit components have different chemical properties. Therefore, the shelf lives of the components are different. The kit has it’s own expiration date which is the same as the expiration date of the first expiring component.