QuikRead go CRP

Accurate measurement of C-reactive protein (CRP) can be critical in the clinical management of a patient with symptoms of infection. The QuikRead go CRP test helps to identify patients who benefit from antibiotics and it is valuable in monitoring the treatment outcome. The easy to use QuikRead go CRP test can be used near the patient and it provides immediate CRP result.

QuikRead go CRP is an efficient tool for point of care settings to guide the treatment decisions of healthcare professionals.

QuikRead go CRP provides reliable and fast results

Reliable results within minutes

• Results are precise, accurate, and comparable to laboratory tests
• Analysis time 2 minutes
• CRP measuring range 5 – 200 mg/l

Easy to use

• No manual steps
• Wide automatic hematocrit correction
• Performed on a finger-prick blood sample. Venous blood, plasma, or serum can also be used

QuikRead go multianalyte point of care system

• Portable instrument and fully automatic testing procedure
• Bi-directional connectivity to most HIS and LIS systems

Test results should never be used alone, without a complete clinical evaluation.

This version of QuikRead go CRP is not registered in the USA (link to the US product version: QuikRead go CRP for the USA).

Regular use of QuikRead go CRP Controls is recommended.

Recommended Controls:

• 153764 QuikRead go CRP Control (~25 mg/l with blue colour) (image)
• 153763 QuikRead go CRP Control High (~75 mg/l with blue colour) (image)

Related products:

• 67962 QuikRead Capillaries (20 µl) (image)
• 67966 QuikRead Plungers (image)

CRP aids clinical management of patients with infections or inflammatory conditions

C-reactive protein (CRP) is an acute-phase plasma protein present in healthy individuals at low concentrations. The median CRP level of healthy people is usually < 0.8 mg/l¹ but the concentration increases fast during bacterial infection, being able to go up to hundreds of mg/l. Bacterial infections and inflammatory conditions stimulate the production of CRP in the liver. From the initial stimulus, CRP levels become detectable in 4-6 hours and peak in 36-48 hours^2,3. CRP production is proportional to the intensity of infection and inflammation. Therefore, it is useful in the evaluation of disease severity. In bacterial infections, CRP may increase relatively high, above 100 mg/l. Viral and self-limiting bacterial infections cause only a minor elevation or not elevation at all. In inflammatory conditions, CRP levels may increase to moderate level, usually being between 10-40 mg/l. When the patient starts responding to treatment, the immune system overcomes the pathogen itself, or the inflammatory stimulus starts settling, CRP levels decrease rapidly back to normal with a half-life of 19h^1,2.

Accurate and precise CRP point of care testing is helpful in the clinical management of patients with infection and in optimizing antibiotic prescribing. The short analytical time and a small sample volume of CRP point of care tests offer a substantial benefit compared to the laboratory CRP test. When used together with the clinical examination of a patient, QuikRead go CRP tests are excellent tools in the following situations:

• differentiation of bacterial and viral infections
• decreasing diagnostic uncertainty and guiding appropriate antibiotic prescribing in acute infections^4,5
• evaluation, monitoring, and prediction of the infection course, inflammation and treatment response^6-8
• ruling out severe bacterial infection⁹

References

1. Shine, B et al. Solid phase radioimmunoassays for C-reactive protein. Clin. Chim. Acta 1981; 117:13–23.
2. Vigushin DM, Pepys MB, Hawkins PN. Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest 1993; 91(4): 1351-1357.
3. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003; 111(12): 1805-1812.
4. Markanday A. Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians. Open Forum Infect Dis 2015; 2(3): ofv098.
5. Little P et al. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet 2013; 382(9899): 1175-1182.
6. Tonkin-Crane SKG et al. Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews (Review). Cohcrane Database of Systematic Reviews 2017; 7(9): CD012252.
7. Bruns AH et al. Usefulness of consecutive C-reactive protein measurements in follow-up of severe community-acquired pneumonia. Eur Respir J 2008; 32(3): 726-732.
8. Verhagen DW et al. Prognostic value of serial C-reactive protein measurements in left-sided native valve endocarditis. Arch Intern Med 2008; 168(3): 302-307.
9. Emery P. Evidence-based review of biologic markers as indicators of disease progression and remission in rheumatoid arthritis. Rheumatol Int 2007; 27(9): 793-806.

Antimicrobial resistance is a global health threat. CRP point of care testing aids management of respiratory infections and fighting against antimicrobial resistance.
Learn more: Antimicrobial resistance and CRP

Marketing and sales materials

QuikRead go CRP and CRP+Hb Brief Instructions (EN)

QuikRead go Family Brochure (EN)

QuikRead go Technical Specifications (EN)

Instructions for Fingertip Blood Collection (EN)

QuikRead go Control Information (EN)

QuikRead go workstation Flyer (EN)

Stories

Targeted antibiotic use in primary healthcare (EN)

Tackling drug-resistant infections globally - the final report published (EN)

Videos

Instructions for use

(For informative use only. Kindly always refer to the latest package insert in the kit.)

QuikRead go CRP IFU (FI, SE, NO, DK), 133891, 135172, 135174

QuikRead go CRP IFU (GB, DE, FR, IT), 135171, 135283

QuikRead go CRP IFU (ES, PT, NL, GB), 135171, 135283

QuikRead go CRP IFU (SI, RS, HR, GR), 135171, 135283

QuikRead go CRP IFU (CZ, SK, HU, PL), 135171, 135283

QuikRead go CRP Controls IFU (GB, DE, FR, ES, IT, CZ, HU, PL, SK, NL, EE, LT, SE, NO, DK, FI), 153765, 153764, 153763

Safety Data Sheet

QuikRead go CRP SDS (EN) 135171, 135283, 133891, 135172, 135174

QuikRead go CRP Control SDS (EN) 153764

QuikRead go CRP Control High SDS (EN) 153763

Is it possible to use QuikRead CRP kits for QuikRead go?

No, for QuikRead go you can only use QuikRead go CRP kits. QuikRead go requires a bar code on the cuvette, whereas QuikRead 101 uses a magnetic card.

The QuikRead go instrument gives me a result of > 200 mg/l, but I would like to get an exact CRP result. Is it possible?

When using plasma/serum samples you can dilute the sample with 0.9 % NaCl before adding it to the cuvette. The recommended dilution is 1+3. Remember to multiply the result by 4.

I accidentally left a QuikRead go CRP kit at room temperature for a weekend. Can I still use it?

Yes, you can use the kit. The kit can be stored at room temperature (18 - 25 °C) for one month. If it is used at room temperature during daily working hours (7.5 hours) and stored at 2 - 8 °C after finishing work, the kit will remain stable for 3 months.

Can I use controls other than QuikRead CRP Controls with the QuikRead go CRP kit?

Yes, you can use other commercially available controls. The acceptable control limits must be defined with the precision results gained with the QuikRead go instrument. The blanking process might not succeed if you use a control which contains artificial red blood cells because they might not haemolyse normally.

Why do QuikRead go CRP kit components have different expiration dates and why does the kit have shorter shelf life than some of the components?

The kit components have different chemical properties. Therefore, the shelf lives of the components are different. The kit has it’s own expiration date which is the same as the expiration date of the first expiring component.