SIBA
SIBA® (Strand Invasion Based Amplification) is Aidian’s proprietary isothermal nucleic acid amplification technology. Please see below how the SIBA technology works
Documents and materials
Scientific articles
Hoser MJ, Mansukoski HK, Morrical SW, Eboigbodin KE (2014) Strand Invasion Based Amplification (SIBA®): A Novel Isothermal DNA Amplification Technology Demonstrating High Specificity and Sensitivity for a Single Molecule of Target Analyte. PLoS ONE 9(11): e112656. doi:10.1371/journal.pone.0112656A
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0112656
Eboigbodin KE & Hoser MJ (2016). Multiplex Strand Invasion Based Amplification (mSIBA) assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. Scientific Reports, 6, 20487. Doi: 10.1038/srep20487
http://www.nature.com/articles/srep20487
Eboigbodin K, Filén S, Ojalehto T, Brummer M, Elf S, Pousi K & Hoser M. Reverse transcription strand invasion based amplification (RT-SIBA): a method for rapid detection of influenza A and B Applied Microbiology and Biotechnology, 2016, April 11. Doi: 10.1007/s00253-016-7491-y.
http://rd.springer.com/article/10.1007%2Fs00253-016-7491-y
Eboigbodin KE, Brummer M, Ojalehto T & Hoser M (2016). Rapid molecular diagnostic test for Zika virus with low demands on sample preparation and instrumentation. Diagnostic microbiology and infectious disease, 86, 369-371. https://doi.org/10.1016/j.diag...
http://www.sciencedirect.com/science/article/pii/S073288931630267X
Eboigbodin KE, Moilanen K, Elf S & Hoser M (2017). Rapid and sensitive real-time assay for the detection of respiratory syncytial virus using RT-SIBA®. BMC Infectious Diseases, 17, 134. Doi: 10.1186/s12879-017-2227-x.
http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2227-x
Posters
SIBA outlicensing opportunities
SIBA® reagent kit is currently available to facilitate discussions for partnering and licensing opportunities between Aidian and its potential partners. The reagent kit is based on SIBA® technology.
We are actively seeking international partnering and licensing opportunities for our proprietary SIBA® technology both in selected human IVD areas, as well as in non-IVD, including areas like veterinary, environmental & food and water. Aidian owns the global rights for the SIBA isothermal nucleic acid detection technology in all fields.
Proven tolerance to sample-derived inhibitors allows the SIBA technology to robustly distinguish closely related species with high sensitivity. The SIBA technology performs at a low and constant temperature avoiding the need of complex thermal cycling instrumentation. The strengths of the SIBA technology allowing a fast and accurate nucleic acid detection favour the use of the technology in a variety of sample types and test settings in a small-footprint device.
Read more: SIBA licensing and partnering opportunities (EN)
For more information please contact us by filling in the contact form.