Please see below how the SIBA technology works
Documents and materials
Hoser MJ, Mansukoski HK, Morrical SW, Eboigbodin KE (2014) Strand Invasion Based Amplification (SIBA®): A Novel Isothermal DNA Amplification Technology Demonstrating High Specificity and Sensitivity for a Single Molecule of Target Analyte. PLoS ONE 9(11): e112656. doi:10.1371/journal.pone.0112656A
Eboigbodin KE & Hoser MJ (2016). Multiplex Strand Invasion Based Amplification (mSIBA) assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. Scientific Reports, 6, 20487. Doi: 10.1038/srep20487
Eboigbodin K, Filén S, Ojalehto T, Brummer M, Elf S, Pousi K & Hoser M. Reverse transcription strand invasion based amplification (RT-SIBA): a method for rapid detection of influenza A and B Applied Microbiology and Biotechnology, 2016, April 11. Doi: 10.1007/s00253-016-7491-y.
Eboigbodin KE, Brummer M, Ojalehto T & Hoser M (2016). Rapid molecular diagnostic test for Zika virus with low demands on sample preparation and instrumentation. Diagnostic microbiology and infectious disease, 86, 369-371. https://doi.org/10.1016/j.diag...
Eboigbodin KE, Moilanen K, Elf S & Hoser M (2017). Rapid and sensitive real-time assay for the detection of respiratory syncytial virus using RT-SIBA®. BMC Infectious Diseases, 17, 134. Doi: 10.1186/s12879-017-2227-x.
SIBA outlicensing opportunities
SIBA® reagent kit is currently available to facilitate discussions for partnering and licensing opportunities between Aidian and its potential partners. The reagent kit is based on SIBA® technology.
We are actively seeking international partnering and licensing opportunities for our proprietary SIBA® technology both in selected human IVD areas, as well as in non-IVD, including areas like veterinary, environmental & food and water. Aidian owns the global rights for the SIBA isothermal nucleic acid detection technology in all fields.
Proven tolerance to sample-derived inhibitors allows the SIBA technology to robustly distinguish closely related species with high sensitivity. The SIBA technology performs at a low and constant temperature avoiding the need of complex thermal cycling instrumentation. The strengths of the SIBA technology allowing a fast and accurate nucleic acid detection favour the use of the technology in a variety of sample types and test settings in a small-footprint device.
For more information please contact us by filling in the contact form.